Treatment burden, adherence, and quality of life in children with daily GH treatment in France


The objective of this study was to describe in a real-life setting the treatment burden and adherence and quality of life (QOL) of children treated with daily injections of growth hormone and their relationship with treatment duration.


This non-interventional, multicenter, cross-sectional French study involved children aged 3–17 years treated with daily growth hormone injections.


Based on a recent validated dyad questionnaire, the mean overall life interference total score (100 = most interference) was described, with treatment adherence and QOL, using the Quality of Life of Short Stature Youth questionnaire (100 = best). All analyses were performed according to treatment duration prior to inclusion.


Among the 275/277 analyzed children, 166 (60.4%) had only growth hormone deficiency (GHD). In the GHD group, the mean age was 11.7 ± 3.2 years; median treatment duration was 3.3 years (interquartile range 1.8–6.4). The mean overall life interference total score was 27.7 ± 20.7 (95% CI (24.2; 31.2)), with non-significant correlation with treatment duration (P = 0.1925). Treatment adherence was good (95.0% of children reported receiving >80% of planned injections over the last month); it slightly decreased with treatment duration (P = 0.0364). Children’s overall QOL was good (81.5 ± 16.6 and 77.6 ± 18.7 according to children and parents, respectively), but subscores of the coping and treatment impact domains were <50. Similar results were observed in all patients independently of the condition requiring treatment.


This real-life French cohort confirms the treatment burden of daily growth hormone injections, as previously reported in an interventional study.

Overview publication

TitleTreatment burden, adherence, and quality of life in children with daily GH treatment in France
DateMarch 28th, 2023
Issue nameEndocrine Connections
Issue numberVolume 12: Issue 4
AuthorsCoutant R, Tauber M, Demaret B, Henocque R, Brault Y, Montestruc F, Chassany O & Polak M
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