Molecular Theranostics in Radioiodine-Refractory Differentiated Thyroid Cancer

Differentiated thyroid cancer (DTC) is the most common subtype of thyroid cancer and has an excellent overall prognosis. However, metastatic DTC in certain cases may have a poor prognosis as it becomes radioiodine-refractory. Molecular imaging is essential for disease evaluation and further management. The most commonly used tracers are [18F]FDG and isotopes of radioiodine. Several other radiopharmaceuticals may be used as well, with different diagnostic performances. This review article aims to summarize radiopharmaceuticals used in patients with radioiodine-refractory DTC (RAI-R DTC), focusing on their different molecular pathways. Additionally, it will demonstrate possible applications of the theranostics approach to this subgroup of metastatic DTC.

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TitleMolecular Theranostics in Radioiodine-Refractory Differentiated Thyroid Cancer
DateAugust 27th, 2023
Issue nameCancers
Issue numberv15.17 p4290
DOI10.3390/cancers15174290
AuthorsPetranović Ovčariček P, Campenni A, de Keizer B, Deandreis D, Kreissl MC, Vrachimis A, Tuncel M & Giovanella L
MTGsMTG8
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