Increase of jump performance during GH treatment in short children born SGA

Background

Short children born small for gestational age (SGA) often have low muscle mass. Studies on maximal isometric grip-force (MIGF) observed lower muscle strength in these children. In contrast to MIGF, jumping is an everyday muscle activity for children. Our hypothesis was that GH treatment would cause an increase in jumping strength. So, we aimed to study jumping by mechanography in short SGA children before and during GH treatment.

Methods

Monocentric prospective longitudinal study in a tertiary pediatric endocrinology center. We studied 50 prepubertal short children (23 females) born SGA (mean age 7.2 y, height -3.24 SDS) during GH treatment (mean dose 45 µg/kg/d). Main outcome measures were Peak jump force (PJF) and peak jump power (PJP) measured by Leonardo® ground reaction force plate at baseline and after 12 months of GH treatment. Mechanography data were compared to sex, age and height related references (SD-Score). Fitness was estimated as PJP/kg body weight by use of the Esslinger-Fitness-Index (EFI).

Results

At start of GH treatment PJP/body weight was low at -1.52 SDS and increased significantly to -0.95 SDS during 12 months of treatment (p<0.001). PJF was low-normal compared to height dependent references and remained unchanged. PJP was normal compared to height dependent references and increased only slightly from -0.34 to -0.19 SDSHT.

Conclusions

Jumping performance (EFI) measured by mechanography increased during one year of GH treatment in short children born SGA.

Overview publication

TitleIncrease of jump performance during GH treatment in short children born SGA
DateApril 18th, 2023
Issue nameFrontiers in Endocrinology
Issue numberv14
DOI10.3389/fendo.2023.1122287
AuthorsSchweizer R, Martin DD & Binder G
MTGsMTG5 MTG6
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