Transition from paediatric to adult healthcare presents unique challenges for adolescents with chronic conditions such as adrenal insufficiency (AI). This process requires careful coordination to ensure continuity of care and support as young patients adapt to managing their condition independently. In the Netherlands, transition care follows a structured, quality-driven approach aimed at meeting the medical, psychological, and social needs of adolescents with chronic conditions. This paper will define key transition-related terms, explain the framework’s five core pillars, explore best practices for transition, and discuss quality indicators and an implementation plan to facilitate effective transition care for AI patients.