Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead

Neuroendocrine tumors, or NETs, are cancer originating in neuroendocrine cells. They are mostly found in the gastrointestinal tract or lungs. Functional NETs are characterized by signs and symptoms caused by the oversecretion of hormones and other substances, but most NETs are non-functioning and diagnosis in advanced stages is common. Thus, novel diagnostic and therapeutic strategies are warranted. Epigenetics may contribute to refining the diagnosis, as well as to identify targeted therapy interfering with epigenetic-sensitive pathways. The goal of this review was to discuss the recent advancement in the epigenetic characterization of NETs highlighting their role in clinical findings.

Overview publication

TitleClinical Epigenetics of Neuroendocrine Tumors: The Road Ahead
DateDecember 15th, 2020
Issue nameFrontiers in Endocrinology
Issue numberv11
DOI10.3389/fendo.2020.604341
AuthorsColao A, de Nigris F, Modica R & Napoli C
Read Read publication