Growth & Genetic Obesity Syndromes (MTG5)
For Growth 5 sub thematic groups are identified based on a different multidisciplinary team and different diagnostic and treatment approaches.
A group of imprinting disorders for which care have been well organised:
Prader Willi Syndrome, Silver Russell Syndrome, and Beckwith Wiedemann Syndrome and a group of Growth hormone and IGF-I insensitivity including Laron and Noonan Syndrome, as well as other overgrowth and growth retardation syndromes.
Rare diseases, affecting growth, with life-long endocrine and metabolic consequences, include imprinting disorders with common molecular mechanisms (Prader Willi, Silver Russell, Beckwith Wiedemann syndromes), a group of patients with GH and/or IGF-I insensitivity and patients with other causes of short stature or overgrowth. This group of disorders needs a multidisciplinary care, networks of physicians around Europe to propose common molecular diagnosis strategies, care and clinical trials. Current challenges focus on improving clinical and molecular diagnosis, personalised therapy, and unraveling long-term consequences of these clinical syndromes, thereby proposing better diagnosis, treatment and information from the prenatal period to adulthood for the patients and their families.