The clinical aspects of pituitary tumour genetics

Pituitary tumours are usually benign and relatively common intracranial tumours, with under- and overexpression of pituitary hormones and local mass effects causing considerable morbidity and increased mortality. While most pituitary tumours are sporadic, around 5% of the cases arise in a familial setting, either isolated [familial isolated pituitary adenoma, related to AIP or X-linked acrogigantism], or in a syndromic disorder, such as multiple endocrine neoplasia type 1 or 4, Carney complex, McCune–Albright syndrome, phaeochromocytoma/paraganglioma with pituitary adenoma, DICER1 syndrome, Lynch syndrome, and USP8-related syndrome. Genetically determined pituitary tumours usually present at younger age and show aggressive behaviour, and are often resistant to different treatment modalities.

Overview publication

ЗаглавиеThe clinical aspects of pituitary tumour genetics
Датафевруари 4th, 2021
Име на изданиеEndocrine
Номер на издаване2021(2)
АвториDénes J & Korbonits M
MTGsMTG6
Read Read publication
 Този текст не е наличен в Български